The Roadmap to Healthcare Transformation and our War Against Cancer
linton Foundation Health Matters Conference 2014

January 2014

Briefing Document on "The Roadmap to Healthcare Transformation" and our War Against Cancer

The 2014 Health Matters: Activating Wellness in Every Generation conference took place in La Quinta, California, on January 13-15. The conference announced 30 new strategic partnerships and reached more than 30.7 million users across Facebook and Twitter, trended #1 on Twitter in the U.S. during the conference, and garnered more than 72,500 views on Livestream.  Learn more

Health Transformation Panel

  • Moderator: President Bill Clinton, Founder, Clinton Foundation
  • Bruce Broussard, President and CEO, Humana Inc.
  • Trevor Fetter, President and CEO, Tenet Healthcare Corporation
  • Tim Finchem, Commissioner, PGA TOUR
  • Sue Siegel, CEO, GE Ventures & healthymagination, GE
  • Patrick Soon-Shiong, MD, Chairman and CEO, NantHealth & Chan Soon-Shiong Family Foundation


Excerpts From Briefing Document to President Clinton 2014

In Summary

At an annual spend of over $2.7 trillion the United States boasts the largest expenditure for healthcare on the planet. This rate of expenditure is unsustainable, threatens the future economic, security and wellbeing of the country. Yet with all this spend the United States faces the paradox that compared to the rest of the world it falls far behind in terms of quality, outcomes and cost!

There is an urgent need, a moral and a financial imperative for this nation to address the ever increasing complexity of medical decision‐making, the deluge of data cluttering the ability for both patient and provider to extract actionable information in real‐time, the disaggregated, dangerous non‐system of care, as well as the ever increasing and unsustainable costs. Building on the aims of the Accountable Care Act, the United States can and should implement a comprehensive transformation of healthcare delivery nationwide. All parts of this health ecosystem must be objectively measured so that patients, providers and payers can achieve better access, better safety and better outcomes, all at lower cost, in real‐time. No such infrastructure exists on a national scale for healthcare.

The National Cooperative, a partnership of the Chan Soon‐Shiong Family Foundation, the Chan Soon‐Shiong Institute for Molecular Medicine, the National Coalition for Health Integration, Celgene Corporation, NantHealth, Bank of America, The Coca‐Cola Company, Verizon Communications, the Clinton Foundation, major academic centers, and health systems. The National Cooperative is pioneering a way for the complex macro‐ecosystem of people and institutions to make their own information available and ask for others’, while keeping the very highest standards for patient privacy in place…a National Healthcare Learning System for best care at lower cost. In part it is a software solution, putting the best computation scholarship to work where it matters most. In part it is a social solution, helping all the participants in the world of healthcare to understand the benefits they would reap from a new approach of collaboration and information sharing for the common good.

The National Cooperative is a commitment by visionary national leaders in philanthropy, academia, and the private sector to chart a new course toward health integration for patients in the United States and to share this innovation with the world. This national initiative reimagines the way patients, doctors, and researchers across the nation can securely access actionable health information at the point of care, in the time of need, for lower cost — a next generation Internet for secure health information, transforming complex big data to evidence based care and a continuously learning healthcare system in America.

January 15, 2014 - President Bill Clinton moderates a discussion on healthcare at the 2014 Clinton Foundation Health Matters Conference. Moderator: President Bill Clinton, Founder, Clinton Foundation Bruce Broussard, President and CEO, Humana Inc.

2014 - Bill Clinton discusses Dr. Patrick Soon-Shiong and the future of cancer care.

Launch of Chan Soon-Shiong Institute of Molecular Medicine

Phoenix Children's Hospital - October 3, 2014

Oxford University - October 23, 2014

Chan Soon-Shiong Institute for Molecular Medicine and the University of Oxford Establish Partnership to Create the First Center for Genomic and Proteomic Medicine in the United Kingdom to Benefit NHS Cancer Patients as Part of a $50M Commitment

The Chan-Soon-Shiong Oxford Center for Molecular Medicine Will Advance Cancer Care with Individualized Information at the Molecular Level and State-of-the-Art Proteomic Technology

“This partnership will evaluate and provide comprehensive molecular diagnostics from genomics to proteomics integrated with clinical data for cancer patients with the aim to identify the right treatment for the right patient at the right time.”

— Anna Schuh, University of Oxford



The Chan Soon-Shiong Institute for Molecular Medicine (CSSIOMM) and the University of Oxford announced a partnership to establish the Chan Soon-Shiong Oxford Center for Molecular Medicine (CSSOCMM), the first of its kind in the United Kingdom designed to support the delivery of individualized, data-driven molecular based medicine for the benefit of NHS cancer patients. The Chan Soon-Shiong Institute has made an initial commitment of $50M to advance clinical cancer care in the UK through genomic and proteomic driven diagnoses. These funds will provide doctors with large-scale sequencing capabilities for patient-level genomic, epigenomic, proteomic, and digital pathology data capture as well as novel tools and supercomputing technology to support critical decision making for cancer treatment. 


Today’s announcement is being made at a press conference in London at which the Minister for Life Sciences, George Freeman MP will preside. Commenting on the announcement, he said: “This investment is a sign that Britain is leading the world in the exciting new field of Genomic Medicine. Breakthroughs in our understanding of how genetics determines how disease really works in patients is crucial to generating new treatments and medicines.

Young Presidents' Organization (YPO) EDGE

February 2014

YPO’s inaugural Global EDGE proved that when you gather 2,000 of the world’s top CEOs in one room, anything can happen. The two-day event held at the Nokia Theatre in Los Angeles, California, came to a close on Thursday, delivering on its theme “Connecting the Stars” with an impressive lineup of more than 40 speakers. 

Dr. Patrick Soon-Shiong spoke with President Bill Clinton onstage about healthcare and cancer care.

CSPAN: Medical Innovation with Senator Lamar Alexander, Senator Michael Bennet, Representative Diana DeGette, and Former Senate Majority Leader Bill Frist

July 2015

july 2015 - watch the c-span report on the bipartisan policy center's forum on medical innovation.

july 2015 - watch the c-span report on the bipartisan policy center's forum on medical innovation.

Senators Lamar Alexander (R-TN), Michael Bennet (D-CO), Representative Diana DeGette (D-CO), former CMS Administrator Mark McClellan, former Senate Majority Leader Bill Frist (R-TN), and former Representative Bart Gordon spoke at a Bipartisan Policy Center forum on medical innovation. They talked about the work being done in Congress to create additional resources for research and to ensure patient safety.

“Advancing Medical Innovation for a Healthier America” was held in the Hart Senate Office Building. 

Breakthroughs in Medicine & Technology Summit, Jackson Hole, WY

August 2015

Clinton, CIA chief visit for conference

Secretive medical event was held at Four Seasons.

Former President Bill Clinton shakes hands with tourists while walking through downtown Jackson on Sunday afternoon. Clinton shopped for about 20 minutes at Valley Bookstore and had coffee at Starbucks before leaving the Town Square.

Former President Bill Clinton shakes hands with tourists while walking through downtown Jackson on Sunday afternoon. Clinton shopped for about 20 minutes at Valley Bookstore and had coffee at Starbucks before leaving the Town Square.

WEDNESDAY, AUGUST 12, 2015 4:30 AM
By Johanna Love

No official word has been given about who was on a government jet parked at Jackson Hole Airport on Aug. 1-3, but the mystery plane’s appearance coincided with a secretive medical conference in Teton Village.

Multiple off-the-record sources told the News&Guide the VIP on the jet was CIA Director John Brennan, in town for the same conference that drew former President Bill Clinton and CNN correspondent Dr. Sanjay Gupta. That would correspond with the U.S. Air Force’s acknowledgement that it had a C-40B in the valley, but the military’s public affairs desk has refused to say who the jet’s passengers were or why it was here.

A C-40B, according to the Air Force’s website, is “designed to be an ‘office in the sky’ for senior military and government leaders,” and its primary users are military combatant commanders. It’s not unobtrusive; the Boeing 737 body it uses is 110 feet long and 41 feet high, with a paint scheme that matches Air Force One.

Meanwhile, the Breakthroughs in Medicine and Technology Summit 2015 brought dozens of people to Four Seasons Resort Jackson Hole. The only information on the Internet about the event comes from three social media channels.

Former U.S. Senate Majority Leader Bill Frist, a 63-year-old heart and lung transplant surgeon, posted four photos from the event on Aug. 1. He said he was there speaking to “some of the leading minds in medicine, science and innovation.” One image shows 25 people in the audience, Frist at a podium and Gupta sitting in a chair onstage in the Cottonwood Ballroom of the Four Seasons.

The next day, Frist posted again on Facebook about the conference, saying, “The future of cancer treatment is in precision medicine and leveraging our ‘natural killer cells.’”

Frist’s policy assistant, Erin Ingraham Rogus, posted an 11-second video on Instagram on Aug. 2 showing Clinton speaking in front of a fireplace at the conference.

“We have one remaining bigotry in America,” Clinton says in the video. “Most of us don’t want to be around anybody who disagrees with us, and we don’t want to get information from anybody who disagrees with us.”
Four Seasons General Manager Michael Mestraud did not return multiple phone calls over a nine-day span. His assistant said he had received the messages but was too busy.

There was widespread online speculation that Clinton used the government jet, but his office said he did not.
Snake River Taxi owner Tyler Pitman, who drove a limousine through the Jackson Hole Aviation gate on the morning of the jet’s departure, said the VIPs he brought to the tarmac were from Atlanta and got on a smaller private jet.

“It would have been cool if it had been” his customers on the Air Force plane, Pitman said. “You never know what you’re going to see here.”

For the full report, click here.

Vice President Joe Biden Meeting at the White House: White Paper on Cancer MoonShot, October 6, 2015

October 6, 2015

Dr. Soon-Shiong meets with Vice President Biden at the White House and presents his white paper on precision medicine in oncology

"The Precision Against Cancer PAC
The Moonshot Program to Develop a Cancer Vaccine for "I am N = 1"

In the way that JFK took us to the moon, this Administration has the opportunity to complete its own moonshot moment: A personalized and revolutionized healthcare system – completely changed for the rest of time, with electronically connected consumers receiving the right care at the right time and the right place. With the advent of next generation genomic sequencing and precision immunotherapies, the exciting possibility of bringing 21st century precision medicine to patients today is very real. Imagine the possibility of creating patient-specific cancer vaccines that can treat and prevent the recurrence of cancer. We no longer have to just dream as this revolution of creating a cancer vaccine for N of 1 is a reality...and can be a lifelong legacy of this Administration."

White House Rose Garden - Vice President Joe Biden Speech: "We Need a MoonShot in This Country to Cure Cancer"

October 21, 2015

Vice President Joe Biden Visits With Scientists and Oncologists in Los Angeles, November 16, 2015 - Dr. Soon-Shiong Presents Concept of 10 Years to 5 Years and a Quantum Leap

November 16, 2015

Exhibit 5 - 2015-11-16 13.16.34.jpg

On November 16, 2015 Vice President Biden visited scientists and oncologists in Los Angeles involved in developing the three pillars of the Cancer MoonShot 2020 program: 

  1. Interoperability & Big Data Analytics
  2. Next Generation Genomic & Proteomic Sequencing
  3. Immunotherapy Combinations Treatment with Demonstration of Natural Killer Cell Manufacturing

At this meeting, Dr. Soon-Shiong introduced the Vice President to Academic, Community Oncologists, and Biotech industry executives involved in the initiative to accelerate clinical trials. 

Cancer MoonShot Coalition Meeting at VP Biden's Naval Observatory Residence, December 2015

December 1, 2015

December 1st Meeting of the National Immunotherapy Coalition and presentation of the Cancer MoonShot 2020 & QUILT Programs to Vice President Biden in Washington DC

The goals of the Cancer MoonShot 2020 Program were presented at a meeting hosted by Vice President Joe Biden at his Naval Observatory residence in Washington DC on December 1, 2015, where members of the Cancer MoonShot 2020 coalition presented their shared vision for translating the promise of immunotherapy and precision medicine through the delivery of combination immunotherapy to routine clinical cancer care, as well as their shared commitment to accelerate the development of immunotherapy and vaccine therapy as the next generation evolution of cancer care. Attendees of that meeting, convened and chaired by Dr. Soon-Shiong, included leadership from the pharmaceutical industry representing large pharma and biotech, leadership from national payers including Independence Blue Cross and Bank of America and healthcare leaders from security and interoperability organizations including Allscripts and Blackberry. 

The Mission: 

A union of forces is needed to successfully implement this opportunity of combinatorial immunotherapies in the war against cancer. The goal is to obtain a commitment by members of the National Immunotherapy Coalition to collectively address the obstacles that may impede rapid clinical implementation of the QUILT Program, by collectively addressing the following issues:

  1. Validation of Big Science: Complex science involving the human immune system and the validation of the safety and efficacy of combination therapy must be tested by reputable scientific enterprises in an unbiased manner without any prejudices other than the interest of the patient. 

  2. Access to novel agents and approved drugs: One of the major challenges facing rapid progress in this field is that numerous pharmaceutical and biotech companies each have their own immunotherapeutic agents in the form of antibodies, immune cells, and vaccines in preclinical and clinical studies. 

  3. FDA Regulation: Novel approaches for the adaptive combination of novel agents in this new paradigm where the combined multi-agents serve as a systems biological approach to the treatment of cancer. 

  4. Care coordination and real-time monitoring of safety and outcomes with integration of complex molecular data, phenotypic data obtained from disparate electronic records. 

  5. Ability to measure outcomes and cost in real time to enable payors to pay for value rather than procedures and establish an adaptive learning system for enhanced predictive modeling.

  6. Network Infrastructure: Highly Secure Bandwidth to Transmit Big Data & Interrogate complex molecular information in large scale. 

Goal:  To validate the potential of combination immunotherapy as the next generation standard of care in cancer patients by completing randomized Phase II trials in patients at all stages of disease in up to 20 tumor types in 20,000 patients, within the next 24-months.  These findings will inform Phase III trials and the Moonshot to Develop a Vaccine Based Immunotherapy for Cancer by 2020.

QUILT: A Quantum Immuno-Oncology Lifelong Trial (QUILT) in patients with cancer undergoing next generation panomic analysis (genome, proteome, immunome and metabolome) to inform precise cancer care based on individualized and dynamic biology of the disease. The protocols will be designed to harness all the elements of the immune system (dendritic, T-Cell, and NK Cell) to combine vaccines and cell based immunotherapy with metronomic chemotherapy and immunomodulators with the goal of durable, long-lasting remission of the disease with the highest quality of life. 

The National Immunotherapy Coalition:  A public-private partnership where a union of forces consisting of the government (NCI, FDA, White House, Congress), Pharma and Biotech Industry, Health Care Providers both academic and community caregivers, insurance industry and self-insured employers, all collectively commit to support this National Immunotherapy Initiative for Cancer.